C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61K 49/00 (2006.01) A61K 51/10 (2006.01) C12N 5/20 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2223291
The present invention is directed to the use of antibodies or binding portions thereof or probes which recognize an antigen of normal, benign, hyperplastic, and cancerous prostate epithelial cells or portions thereof. These antibodies or binding portions thereof or probes can be labeled and used for detection of such cells. They also can be used alone or bound to a substance effective to ablate or kill such cells as a therapy for prostate cancer. Also disclosed is a hybridoma cell line which produces a monoclonal antibody recognizing antigens of normal, benign, hyperplastic, and cancerous prostate epithelial cells or portions thereof.
L'invention concerne l'utilisation d'anticorps ou de parties de liaisons d'anticorps ou de sondes reconnaissant un antigène de cellules épithéliales de la prostate normales, bénignes, hyperplasiques et cancéreuses, ou de parties de celles-ci. Ces anticorps ou les parties de liaison de ces anticorps ou les sondes peuvent être marqués et utilisés pour la détection de telles cellules. Ils peuvent également être utilisés seuls ou liés à une substance efficace pour couper ou tuer ces cellules à titre de traitement du cancer de la prostate. Est également décrite une lignée d'hybridomes produisant un anticorps monoclonal reconnaissant les antigènes de cellules épithéliales de la prostate normales, bénignes, hyperplasiques et cancéreuses, ou des parties de celles-ci.
Cornell Research Foundation Inc.
Gowling Lafleur Henderson Llp
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