Memory-enhancing compositions containing dioxopiperidine...

Details Memory-enhancing compositions containing dioxopiperidine... Memory-enhancing compositions containing dioxopiperidine...

A - Human Necessities

61

K

167/232

A61K 31/00 (2006.01) A61K 31/445 (2006.01)

Patent

CA 2002617

- 28 - ABSTRACT MEMORY-ENHANCING COMPOSITIONS CONTAINING DIOXOPIPERIDINE DERIVATIVES Phenyl-3-aminoalkyl-4-methyl-2,6-dioxopiperidines of the Formula I Image (I) wherein: R1 represents hydrogen or C1-C4 alkyl; n is 1 or 2; R2 represents hydrogen or methyl, provided that one R2 is hydrogen when n is 2; R3 represents hydrogen or C1-C2 alkyl; R4 represents C1-C2 alkyl; R5 and R6 independently represent hydrogen or methyl; m is 0 to 3; and each Y is in a meta or para position and - 29 - independently represents hydroxy, C1-C2 alkoxy, C1-C2 alkyl, C1-C2 hydroxyalkyl, halogen, or trifluoromethyl, provided that hydroxy and alkoxy are not in the para position, and pharmacologically acceptable salts thereof have memory enhancing activity and are particularly useful in the treatment of cognitive deficiencies such as senile dementia. The presently preferred compound is 3-(3'methoxyphenyl)-3-(3"-N,N-dimethylaminopropyl)- 4,4-dimethyl-2,6-dioxopiperidine (AGN 2979).

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