C - Chemistry – Metallurgy – 08 – F
Patent
C - Chemistry, Metallurgy
08
F
C08F 293/00 (2006.01) A61K 47/30 (2006.01) C08F 2/12 (2006.01) C08F 4/42 (2006.01) C08F 218/16 (2006.01) C08G 63/02 (2006.01) C08G 63/46 (2006.01) C08G 63/664 (2006.01) C08L 53/00 (2006.01) C08L 71/02 (2006.01) C08L 67/00 (2006.01)
Patent
CA 2430442
Because hydrophobic drugs are difficult to release by diffusion through matrices of hydrophilic polysaccharides, synthesis of compatibilizers was undertaken. Using a natural hydrophobic polyester: poly([R]-3-hydroxybutyric acid), PHB, possessing a high enthalpy of crystallization, a self assembly amphiphilic system was created. Diblock copolymers of monomethoxy poly(ethylene glycol), mPEG and PHB were synthesized in a one-step, solvent-free, transesterification reaction. The resulting diblock copolymers were used to form colloidal suspensions of nanoparticles that are potential drug carriers and compatibilizers. Catalyzed transesterification in the melt is used to produce diblock copolymers of poly([R]-3-hydroxybutyric acid), PHB, and monomethoxy polyethylene glycol), mPEG, in a one-step process. Bacterial PHB of high molecular weight is depolymerized by two consecutive and simultaneous reactions: pyrolysis and transesterification. The formation of diblocks is accomplished by the nucleophilic attack from the hydroxyl end-group of the mPEG catalyzed by bis-(2-ethylhexanoate) tin. The resulting diblock copolymers are amphiphilic and self assemble into sterically stabilized colloidal suspensions of PHB crystalline lamellae.
Marchessault Robert H.
Ravanelle Francois
Marchessault Robert H.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Ravanelle Francois
University Mcgill
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