Methods for treating stress disorders using glucocorticoid...

A - Human Necessities – 61 – K

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A61K 31/59 (2006.01) A61K 31/56 (2006.01) A61K 31/57 (2006.01)

Patent

CA 2440605

This invention generally pertains to the field of psychiatry. In particular, this invention pertains to the discovery that agents which inhibit the binding of cortisol to its receptors can be used in methods for treating stress disorders. Mifepristone, a potent specific glucocorticoid receptor antagonist, can be used in these methods. The invention also provides a kit for treating stress disorders in a human including a glucocorticoid receptor antagonist and instructional material teaching the indications, dosage and schedule of administration of the glucocorticoid receptor antagonist.

L'invention concerne généralement le domaine de la psychiatrie. Notamment, la découverte que des agents inhibant la liaison du cortisol par rapport à ses récepteurs soit utilisée dans des méthodes de traitement des troubles du stress. La mifépristone, un puissant antagoniste spécifique du récepteur des glucocorticoïdes, peut être utilisée dans ces méthodes. L'invention concerne aussi un nécessaire destiné au traitement des troubles du stress chez un être humain comportant un antagoniste du récepteur des glucocorticoïdes et du matériel didactique comportant les indications, le dosage et le programme d'administration de l'antagoniste du récepteur des glucocorticoïdes.

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