A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A01K 67/027 (2006.01) A61K 31/7088 (2006.01) A61K 38/00 (2006.01) A61K 38/17 (2006.01) A61K 38/19 (2006.01) A61K 39/395 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01) C07K 14/535 (2006.01) C12N 15/85 (2006.01) C12N 15/90 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2496485
The present invention relates generally to a method for treating or preventing or otherwise ameliorating the effects of inflammatory conditions such as but not limited to chronic immune-mediated inflammatory diseases. The present invention further provides pharmaceutical compositions comprising agents which inhibit one or more inflammatory cytokines and/or which down-regulate expression of genes which encode inflammatory cytokines. Such compositions are useful in the treatment and prophylaxis of inflammatory conditions such as inflammatory arthritis amongst other chronic immune-mediated inflammatory diseases. The present invention further provides an animal model for studying the kinetics of and/or screening for agents useful in the treatment or prophylaxis of inflammatory conditions.
L'invention concerne généralement une méthode de traitement et de prévention ou sinon de soulagement des effets de troubles inflammatoires comprenant de manière non exhaustive des maladies inflammatoires à médiation immune chronique. L'invention concerne également des compositions pharmaceutiques comprenant des agents inhibant une ou plusieurs cytokines inflammatoires et/ou régulant vers le bas l'expression de gènes codant des cytokines inflammatoires. De telles compositions sont utiles pour le traitement et pour la prophylaxie de troubles inflammatoires, notamment l'arthrite inflammatoire, entre autres, parmi des maladies inflammatoires à médiation immune chronique. L'invention concerne encore un modèle animal permettant l'étude de la cinétique et/ou le criblage d'agents utiles pour le traitement ou pour la prophylaxie de troubles inflammatoires.
Campbell Ian Keith
Lawlor Kathryn Elizabeth
Metcalf Donald
Roberts Andrew Warwick
Wicks Ian Peter
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
The Walter And Eliza Hall Institute Of Medical Research
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