Synthetic antibody phage libraries

Details Synthetic antibody phage libraries Synthetic antibody phage libraries

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) C07K 14/01 (2006.01) C07K 16/00 (2006.01) C07K 19/00 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/13 (2006.01) C12N 15/85 (2006.01) C40B 40/08 (2006.01) C40B 40/10 (2006.01)

Patent

CA 2510003

The invention provides immunoglobulin polypeptides comprising variant amino acids in CDRs of antibody variable domains. In one embodiment, the polypeptide is a variable domain of a monobody and has a variant CDRH3 region. These polypeptides provide a source of great sequence diversity that can be used as a source for identifying novel antigen binding polypeptides. The invention also provides these polypeptides as fusion polypeptides to heterologous polypeptides such as at least a portion of phage or viral coat proteins, tags and linkers. Libraries comprising a plurality of these polypeptides are also provided. In addition, methods of and compositions for generating and using these polypeptides and libraries are provided.

L'invention concerne des polypeptides d'immunoglobuline comprenant des variantes d'acides aminés dans des CDR de domaines variables d'anticorps. Dans un mode de réalisation, le polypeptide est un domaine variable d'un monocorps et possède une variante de la zone de CDRH3. Ces polypeptides constituent une source de grande diversité de séquences pouvant être utilisée en tant que source d'identification de nouveaux polypeptides de liaison à l'antigène. L'invention porte également sur lesdits polypeptides utilisés en tant que polypeptides de fusion vis-à-vis de polypeptides hétérologues, tels qu'au moins une partie de protéines enveloppes virales, des étiquettes et des segments de liaison. Des banques comprenant plusieurs de ces polypeptides sont également prévues. Par ailleurs, des procédés et des compositions pour la génération et l'utilisation desdits polypeptides et banques sont décrits.

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