Bicyclopolyazamacrocyclocarboxylic acid complexes, their...

Details Bicyclopolyazamacrocyclocarboxylic acid complexes, their... Bicyclopolyazamacrocyclocarboxylic acid complexes, their...

C - Chemistry, Metallurgy

08

B

C08B 37/02 (2006.01) A61K 31/555 (2006.01) A61K 38/00 (2006.01) A61K 47/48 (2006.01) A61K 49/04 (2006.01) A61K 51/04 (2006.01) A61K 51/10 (2006.01) C07D 471/08 (2006.01) C07D 487/08 (2006.01) C07F 5/00 (2006.01) C07F 13/00 (2006.01) C07F 15/00 (2006.01) C07K 14/00 (2006.01) C07K 16/00 (2006.01)

Patent

CA 2103554

Complexes of bicyclopolyazamacrocyclocarboxylic acid with Gd, Mn or Fe ions are disclosed. The complexes can be cova- lently attached to a biologically active molecule, e.g. an antibody or antibody fragment, to form conjugates. The complexes and conjugates are useful as contrast agents for diagnostic purposes. Processes for preparing both the complex and conjugate are dis- closed.

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