Process for the obtaining of hmg-coa reductase inhibitors of...

Details Process for the obtaining of hmg-coa reductase inhibitors of... Process for the obtaining of hmg-coa reductase inhibitors of...

C - Chemistry, Metallurgy

12

P

C12P 17/06 (2006.01) C07D 309/30 (2006.01) C12P 7/42 (2006.01) C12P 7/62 (2006.01)

Patent

CA 2321052

A process for the isolation and purification of HMG-CoA reductase inhibitors from a mycelium biomass is described, which process comprises: clarifying a mycelium broth and concentrating the clarified broth to a lower volume, acidifying of the concentrate to a pH value in the range of 4.5 to 7.5, followed by extracting the HMG-CoA reductase inhibitor with ethyl acetate, crystallization of the HMG-CoA reductase inhibitor from a water-miscible or water-soluble organic solvent, and crystallization of the HMG-CoA reductase inhibitor from an organic solvent having limited miscibility or solubility with water. The crystallization steps may also be reverse. The concept of a combination of the specified crystallization steps can also be used for the purification of a crude HMG-CoA reductase inhibitor.

L'invention concerne un procédé d'isolement et de purification d'inhibiteurs de la HMG-CoA réductase (3-hydroxy-3-méthylglutaryl-coenzymeA réductase), à partir d'une biomasse de mycélium, comprenant les étapes consistant: à clarifier un bouillon de mycélium et à concentrer ce bouillon clarifié en réduisant son volume, à acidifier le concentrât pour lui donner une valeur de pH de l'ordre de 4,5 à 7,5, puis à extraire l'inhibiteur de la HMG-CoA réductase au moyen d'acétate d'éthyle, à cristalliser cet inhibiteur à partir d'un solvant organique miscible ou soluble dans l'eau, et à cristalliser cet inhibiteur à partir d'un solvant organique possédant une miscibilité ou solubilité limitée dans l'eau. On peut également inverser les étapes de cristallisation et utiliser le concept de combinaison des étapes de cristallisation dans la purification d'un inhibiteur brut de la HMG-CoA réductase.

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