Oxazole derivatives and their use as insulin sensitizers

Details Oxazole derivatives and their use as insulin sensitizers Oxazole derivatives and their use as insulin sensitizers

C - Chemistry, Metallurgy

07

D

C07D 263/32 (2006.01) A61K 31/421 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2490152

Compound of formula (I): and pharmaceutically acceptable salts and esters thereof, wherein R1 is aryl; R2 is hydrogen, alkyl or cycloalkyl; R3 is hydrogen, alkyl, aralkyl, aryl, alkylcarbonyl, arylcarbonyl, alkyl-S(O)2- or aryl-S(O)2- ; R4 is aralkyl; R5, R6, R7 and R8 are independently selected from hydrogen, alkyl or cycloalkyl; and n is 1,2,3,4 or 5, are useful as insulin sensititers, particularly PPAR activators.

L'invention concerne les composés représentés par la formule (I): (I), ainsi que les sels et les esters pharmaceutiquement acceptables de ceux-ci. R?1¿ représente aryle; R?2¿ représente hydrogène alkyle ou cycloalkyle ; R?3¿ représente hydrogène, alkyle, aralkyle, aryle, alkylcarbonyle, arylcarbonyle, alkyl-S(O)¿2?- or aryl-S(O)¿2?-; R?4¿ représente aralkyle; R?5¿, R?6¿, R?7¿ et R?8¿ sont choisis séparément parmi l'hydrogène, l'alkyle ou le cycloalkyle ; et n représente 1,2,3,4 ou 5. Ces composés peuvent être utilisés en tant que sensibilisateurs à l'insuline, en particulier en tant qu'activateurs des PPAR.

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