Tumor therapy with alphavirus-based and high affinity...

Details Tumor therapy with alphavirus-based and high affinity... Tumor therapy with alphavirus-based and high affinity...

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 31/70 (2006.01) A61K 35/76 (2006.01) A61K 38/20 (2006.01) A61P 35/00 (2006.01) C12N 15/86 (2006.01)

Patent

CA 2440890

The present invetion relates to methods and compositions for treating tumors using vectors that preferentially target tumor cells. In particular, the invention relates to alphavirus-based, preferably Sindbis virus-based, vectors and to non-alphavirus-based vectors, which have a preferential affinity for high affinity laminin receptors (HALR). These vectors are efficiently targeted to tumors and ahve the ability to cause tumor necrosis.

La présente invention concerne des méthodes et des compositions destinées à traiter des tumeurs au moyen de vecteurs qui visent de préférence les cellules tumorales. Plus précisément, l'invention se rapporte à des vecteurs basés sur l'alphavirus et de préférence sur le virus Sindbis, ainsi qu'à des vecteurs non basés sur l'alphavirus, et présentant une affinité préférentielle pour les récepteurs à haute affinité de la laminine (HALR). Ces vecteurs sont efficacement ciblés sur des tumeurs et présentent la capacité à induire une nécrose tumorale.

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