Adamts-8 proteins and uses thereof

Details Adamts-8 proteins and uses thereof Adamts-8 proteins and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 9/64 (2006.01) A61K 38/46 (2006.01)

Patent

CA 2562683

The present invention features methods of using ADAMTS-8 proteins or their functional derivatives to cleave aggrecan or other proteoglycan molecules. The present invention also features methods for identifying ADAMTS-8 modulators that are capable of inhibiting or enhancing ADAMTS-8 proteolytic activities. In addition, the present invention features pharmaceutical compositions comprising ADAMTS-8 proteins or their derivatives or modulators. These pharmaceutical compositions can be used to treat diseases that are characterized by deficiencies or abnormalities in proteoglycan cleavage or metabolism.

La présente invention comporte des procédés d'utilisation de protéines de type ADAMTS-8 ou de leurs dérivés fonctionnels afin de diviser des molécules d'aggrecan ou autres molécules de proteoglycan. La présente invention comporte également des procédés destinés à identifier des modulateurs d'ADAMTS-8 qui peuvent inhiber ou augmenter les activités protéolytiques d'ADAMTS-8. De plus, la présente invention comporte des compositions pharmaceutiques comprenant des protéines d'ADAMTS-8 ou leurs dérivés ou modulateurs. Ces compositions pharmaceutiques peuvent être utilisées pour traiter des maladies qui sont caractérisées par des déficiences ou des anomalies dans la division ou le métabolisme du proteoglycan.

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