C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 15/248 (2006.01) A61K 31/704 (2006.01) A61P 21/00 (2006.01)
Patent
CA 2528223
The present invention relates to colchicine derivatives, in particular to the 3-demethyl and 3-demethylthio-colchicine of the general formula (I) in which X is oxygen or sulfur, a method for the preparation thereof and pharmaceutical compositions containing them. The compounds of formula (I) have muscle relaxing, anti-inflammatory and anti-gout activity.
La présente invention concerne des dérivés de colchicine, notamment la 3-déméthyle et 3-déméthylthio-colchicine de la formule générale (I) dans laquelle X représente oxygène ou soufre, un procédé pour sa préparation et des compositions pharmaceutiques les contenant. Les composés de la formule (I) présentent une activité myorelaxante, anti-inflammatoire et anti-goutte.
Bombardelli Ezio
Fontana Gabriele
Indena S.p.a.
Kirby Eades Gale Baker
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