C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 263/32 (2006.01) C07D 417/10 (2006.01)
Patent
CA 2111445
This invention is directed to a process for preparing a compound of the formula Image ; wherein X is Image . The process utilizes 2-3 equivalents of a borane reducing agent and is run in the presence of a chiral oxazoborolidine catalyst. The product of this stereoselective reduction is a chiral alcohol which is useful in the synthesis of certain potent thiazolidine-2,4-dione hypoglycemic compounds.
Limited Pfizer
Smart & Biggar
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