C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 19/04 (2006.01) C07H 1/06 (2006.01) C07H 21/00 (2006.01) G01N 27/447 (2006.01)
Patent
CA 2177958
Disclosed is a substrate useful for separating unmodified and modified mononucleotides and oligonucleotides. The substrate includes at least 12 % (weight: volume) polymer in at least 5 M urea and at least 32 % (volume: volume) organic solvent, the organic solvent being a chemically stable liquid at room temperature and having a dielectric constant of at least 20. Also provided is a method of separating unmodified and modified mononucleotides and/or oligonucleotides utilizing this substrate.
La présente invention concerne un substrat utile pour la séparation de mononucléotides et d'oligonucléotides modifiés ou non. Le substrat comporte au minimum 12 % de polymère (poids/volume) dans au moins 5M d'urée, ainsi qu'un minimum de 32 % de solvant organique (volume/volume), lequel est, à température ambiante, un liquide chimiquement stable à constante diélectrique d'au moins 20. L'invention concerne également un procédé utilisant ce substrat pour la séparation de mononucléotides et d'oligonucléotides modifiés ou non.
Bourque Andre
Cohen Aharon
Vilenchik Maria
Hybridon Inc.
Mbm & Co.
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