Agents binding specifically to biotin for detecting damaged...

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/68 (2006.01) C07D 473/18 (2006.01) C07D 473/34 (2006.01) C07H 19/173 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2222513

The present invention relates to agents for use in a method of detection of 8- oxoguanine, 8-oxodeoxyguanosine, 8-oxoadenine and 8-oxodeoxyadenosine comprising a molecule which binds specifically to biotin and to any one of 8-oxoguanine, 8-oxodeoxyguanosine, 8-oxoadenine and 8-oxodeoxyadenosine, together with methods for the detection of damaged nucleic acid bases.

La présente invention a pour objet des agents destinés à servir dans un procédé de détection de 8-oxoguanine, 8-oxodésoxyguanosine, 8-oxoadénine et 8-oxodésoxyadénosine, comprenant une molécule se liant spécifiquement avec la biotine et avec l'un des composés précités. L'invention concerne également des procédés de détection de bases d'acides nucléiques endommagés.

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