Benzenesulfonamide derivatives and their use as mek inhibitors

Details Benzenesulfonamide derivatives and their use as mek inhibitors Benzenesulfonamide derivatives and their use as mek inhibitors

C - Chemistry, Metallurgy

07

C

C07C 311/39 (2006.01) A61K 31/18 (2006.01) A61P 5/48 (2006.01) A61P 17/06 (2006.01) A61P 19/02 (2006.01) A61P 25/28 (2006.01) A61P 31/18 (2006.01) A61P 35/00 (2006.01) A61P 37/06 (2006.01)

Patent

CA 2349832

Benzenesulfonamides of formula (I), in which W is OR1, NR2OR1, NRARB, NR2NRARB, or NR2(CH2)2-4NRARB and the other variables as de fined in the claims, are inhibitors of MEK and are effective in the treatment of proliferative diseases, cancer, stroke, heart failure, xenograft rejection, arthritis, cystic fibrosis, hepatomegaly, cardiomegaly, Alzheimer's disease, complications of diabetes, septic shock, and viral infection.

L'invention concerne des benzénesulfonamides de la formule (I), dans laquelle W est OR¿1?, NR¿2?OR¿1?, NR¿A?R¿B?, NR¿2?NR¿A?R¿B?, ou NR¿2?(CH¿2?)¿2-4?NR¿A?R¿B?. Les autres variables, telles que définies dans les revendications, qui sont des inhibiteurs de MEK, sont efficaces dans le traitement de maladies proliférantes, du cancer, d'accidents vasculaires cérébraux, de défaillance cardiaque, de rejet d'hétérogreffes, d'arthrite, de fibrose cystique, d'hépatomégalie, de cardiomégalie, de maladie d'Alzheimer, de complications du diabète, de choc septique et d'infection virale.

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