New self emulsifying drug delivery system

Details New self emulsifying drug delivery system New self emulsifying drug delivery system

A - Human Necessities

61

K

A61K 9/113 (2006.01) A61K 9/48 (2006.01) A61K 31/216 (2006.01)

Patent

CA 2401857

The present invention claims and discloses a pharmaceutical composition suitable for oral administration, in form of an emulsion pre-concentrate, comprising (i) a compound of formula (I); (ii) one or more surfactants; (iii) optionally an oil or semi-solid fat; said composition forming an in-situ oil- in-water emulsion upon contact with aqueous media such as gastrointestinal fluids. The composition may optionally also comprise one or more short-chain alcohols. The pharmaceutical composition is useful in the treatment of pain and inflammation.

L'invention concerne une composition pharmaceutique adaptée à l'administration orale et se présentant sous la forme d'un pré-concentré d'émulsion. Cette composition contient (i) un composé da la formule (I); (ii) au moins un tensio-actif; (iii) éventuellement une huile ou une graisse semi-solide. Au contact avec un milieu aqueux tel que les fluides gastro-intestinaux, cette composition forme in-situ une émulsion huile-eau. La composition peut éventuellement comprendre au moins un alcool à courte chaîne. La composition pharmaceutique est utile dans le traitement de douleurs et d'inflammations.

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