C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/395 (2006.01) A61K 31/41 (2006.01) A61P 31/14 (2006.01) C07K 5/08 (2006.01) C07K 14/81 (2006.01) C12N 9/50 (2006.01)
Patent
CA 2656816
The present invention relates to compounds of Formula (I), (II), (III) or (IV), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising a compound of the present invention.
La présente invention concerne des composés de formule I, II, III ou IV, ou leurs sels, esters ou prodrogues pharmaceutiquement acceptables : qui inhibent l'activité des sérine protéases, en particulier l'activité de la protéase NS3-NS4A du virus de l'hépatite C (VHC). En conséquence, les composés de la présente invention perturbent le cycle vital du virus de l'hépatite C et ils sont également utiles comme agents antiviraux. La présente invention concerne en outre des compositions pharmaceutiques comprenant les composés ci-dessus, destinées à être administrées à un sujet atteint d'une infection par le VHC. L'invention concerne également des procédés de traitement d'une infection par le VHC chez un sujet en administrant une composition pharmaceutique comprenant un composé de la présente invention.
Liu Dong
Or Yat Sun
Sun Ying
Wang Zhe
Enanta Pharmaceuticals Inc.
Gowling Lafleur Henderson Llp
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