Positive inotropic and lusitropic pyrroloquinolinone...

C - Chemistry – Metallurgy – 07 – D

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Details

C07D 471/04 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) C07D 207/448 (2006.01) C07D 401/00 (2006.01) C07D 403/00 (2006.01) C07D 405/14 (2006.01)

Patent

CA 2163122

The present invention relates to novel positive inotropic and lusitropic compounds of formula (I), the pharmaceutical acceptable acid addition salts thereof and the stereochemically isomeric forms thereof wherein L is a radical of formula -O-Alk-(NH)p-C(=O)- R1, pharmaceutical composition thereof, methods of preparing said compounds, intermediates in the preparation thereof, and use of said compound for the treatment of congestive heart failure. (See formula I)

La présente invention se rapporte à de nouveaux composés à propriétés inotropes et lusitropes positives, de la formule (I), à leur sels d'addition d'acide pharmaceutiquement acceptables ainsi qu'à leur formes stéréochimiquement isomères, formule dans laquelle L représente un radical de la formule -O-Alk-(NH)p-C(=O)-R<1> et à leurs compositions pharmaceutiques. L'invention se rapporte également à des procédés de préparation de ces composés, et à des intermédiaires utilisés pour leur préparation.

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