Swellable biodegradable polymeric matrices and methods

Details Swellable biodegradable polymeric matrices and methods Swellable biodegradable polymeric matrices and methods

C - Chemistry, Metallurgy

08

F

C08F 283/00 (2006.01) A61K 47/00 (2006.01) C08F 283/06 (2006.01) C08F 289/00 (2006.01) C08L 51/00 (2006.01) C08L 53/00 (2006.01)

Patent

CA 2741415

The invention provides biodegradable polymeric hydrogel matrices having excellent durability and swellability. The matrices are formed from a combination of poly-.alpha.(1 >4)glucopyranose macromer and a biocompatible biostable hydrophilic macromer. The matrices can be used in association with a medical device or alone. In some methods the polymeric matrix is placed or formed at a target site in which the matrix swells and occludes the target area, and is able to be degraded at the target site after period of time.

Linvention concerne des matrices biodégradables dhydrogel polymère, ayant une excellente durabilité et une excellente aptitude au gonflement. Les matrices sont formées à partir dune combinaison de macromères poly-a(l>4)­glucopyranose et dun macromère hydrophile biostable et biocompatible. Les matrices peuvent être utilisées en association avec un dispositif médical, ou seules. Dans certains procédés, la matrice polymère est placée ou formée en un site cible, dans lequel la matrice gonfle et ferme les zones cibles, et est capable dêtre dégradée sur le site cible après un certain temps.

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