C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) A61K 31/7088 (2006.01) A61K 39/118 (2006.01) A61K 48/00 (2006.01) A61P 31/04 (2006.01) C07K 14/275 (2006.01) C07K 14/295 (2006.01) C07K 16/12 (2006.01) C07K 19/00 (2006.01) C12N 15/70 (2006.01) C12P 21/00 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2424545
The invention discloses the Chlamydia PMPE and PMPI polypeptide, polypeptides derived therefor, (PMP-derived polypeptides), nucleotide sequences encoding said polypeptides, antibodies that specifically bind the PMP polypeptides and PMP-derived polypeptides and T-cells specific for PMP polypeptides and PMP- derived polypeptides. Also disclosed are prophylactic and therapeutic compositions, including immunogenic compositions, e.g., vaccines, comprising PMP polypeptides or PMP-derived polypeptides or antibodies thereto. The invention additionally discloses methods of inducing in animals an immune response to Chlamydia cells, Chlamydia elementary bodies, and/or cells expressing Chlamydial proteins, e.g., cell infected with Chlamydia.
La présente invention concerne le polypeptide PMPE et PMPI de chlamydia, des polypeptides dérivés de celui-ci (polypeptides dérivés de PMP), des séquences nucléotidiques codantes pour ces polypeptides, des anticorps qui se lient spécifiquement à ces polypeptides PMP et à ces polypeptides dérivés de PMP et des lymphocytes T spécifiques pour ces polypeptides PMP et ces polypeptides dérivés de PMP. Cette invention concerne aussi des compositions prophylactiques et thérapeutiques, comprenant des composition immunogènes, par exemple des vaccins, comprenant ces polypeptides PMP, ces polypeptides dérivés de PMP ou des anticorps de ceux-ci. Cette invention concerne enfin des techniques permettant d'induire chez des animaux une réponse immunitaire des cellules à chlamydia, des corps élémentaires de chlamydia, et/ou des cellules exprimant les protéines de chlamydia, par exemple une cellule infectée par chlamydia.
Antex Biologics Inc.
Emergent Product Development Gaithersburg Inc.
Osler Hoskin & Harcourt Llp
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