Substituted bicyclic pyrimidinones as a mitotic kinesin ksp...

Details Substituted bicyclic pyrimidinones as a mitotic kinesin ksp... Substituted bicyclic pyrimidinones as a mitotic kinesin ksp...

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/517 (2006.01) A61K 31/5377 (2006.01) A61K 31/5513 (2006.01) A61P 35/00 (2006.01) C07D 239/70 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 403/06 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2468266

The present invention relates to cycloalkylpyrimidinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.

La présente invention concerne des composés cycloalkylpyrimidinones utilisés pour traiter des maladies prolifératives cellulaires et des symptômes associés à l'activité de la kinésine KSP, et pour inhiber la kinésine KSP. La présente invention concerne également des compositions comprenant ces composés ainsi que des méthodes permettant de les utiliser pour traiter le cancer chez des mammifères.

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