Highly fluorinated, chloro-substituted organic...

Details Highly fluorinated, chloro-substituted organic... Highly fluorinated, chloro-substituted organic...

B - Operations, Transporting

01

J

B01J 13/00 (2006.01) A01N 1/02 (2006.01) A61K 9/00 (2006.01) A61K 9/107 (2006.01) A61K 31/02 (2006.01) A61K 31/08 (2006.01) A61K 49/00 (2006.01) A61K 49/04 (2006.01) A61K 49/18 (2006.01) C07C 43/12 (2006.01) C07C 43/313 (2006.01)

Patent

CA 2125401

This invention relates to compositions comprising highly fluorinated, chloro- substituted, non-cyclic organic compounds having 7 to 9 carbon atoms and to processes of using them. More particularly, this invention relates to emulsions comprising those highly fluorinated, chloro-substituted organic compounds in a sufficiently high concentration to be effective in the desired level of oxygen transport, which emulsions are capable of sterilization; have long term stability, persist for sufficiently long times in the bloodstream to deliver useful quantities of oxygen, yet be eliminated rapidly enough from the body to avoid toxicity arid retention in body parts and organs. This invention also relates to emulsions comprising non-cyclic perfluorochloroethers having 7 to 10 carbon atoms, preferably 7 to 9 carbon atoms, especially perfluoro-bis- chlorobutyl ether. These novel emulsions have various medical and oxygen transport applications, such as "artificial blood" and preserving organs.

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