Vitamin d receptor agonists and uses thereof

Details Vitamin d receptor agonists and uses thereof Vitamin d receptor agonists and uses thereof

C - Chemistry, Metallurgy

07

C

C07C 401/00 (2006.01) A61K 31/59 (2006.01) A61P 7/00 (2006.01) A61P 9/00 (2006.01)

Patent

CA 2758698

Disclosed is a compound of Formula (I), in which R1, R2, R3, R4, R5, R6, X, and a are defined herein, or a pharma-ceutically acceptable salt thereof. Also disclosed are a pharmaceutical composition comprising a compound or salt therof of For-mula (I) and a method of treating a disease which benefits from the modulation of the vitamin D receptor, such as a bone disorder, cardiovascular disease, a cardiovascular complication associated with renal disease, endothelial dysfunction, hyperparathyroidism, hypocalcemia, an immune disorder, left ventricular hypertrophy, a proliferative disease, proteinuria, renal disease, and thrombosis.

La présente invention concerne un composé selon la formule (I), dans laquelle R1, R2, R3, R4, R5, R6, X et a sont définis dans la description, ou un sel pharmaceutiquement acceptable de ce composé. La présente invention concerne également une composition pharmaceutique comprenant un composé ou un sel du composé de formule (I) et un procédé de traitement d'une maladie contre laquelle la modulation du récepteur de la vitamine D est bénéfique, comme une affection osseuse, une maladie cardiovasculaire, une complication cardiovasculaire associée à la rénopathie, un dysfonctionnement endothélial, l'hyperparathyroïdisme, l'hypocalcémie, un trouble immunitaire, l'hypertrophie du ventricule gauche, une maladie proliférative, la protéinurie, la rénopathie et la thrombose.

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