Indoles

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C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/404 (2006.01) A61P 29/00 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2670139

The present invention is concerned with novel indol-2-yl-carbonyl-piperidine derivatives as V1a receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use as medicaments. The active compounds of the present invention are useful in the prevention and/or treatment of anxiety and depressive disorders 5 and other diseases. Present invention is concerned with compounds of the general formula (I), A: (a), (b), (c) wherein R1 to R6, R8 to R14, R12', R13', X and Y are as defined in the specification.

Cette invention concerne des dérivés d'indol-2-yl-carbonyl-pipéridine en tant qu'antagonistes du récepteur V1a ainsi que leur fabrication, des compositions pharmaceutiques les renfermant et leurs utilisations comme médicaments. Les composés actifs de l'invention conviennent pour la prévention et/ou le traitement de l'angoisse et de troubles à caractère dépressif et autres pathologies. La présente invention concerne des composés représentés par la formule générale (I), A: (a), (b), (c), dans laquelle. Dans cette formule dans laquelle R1 à R6, R8 à R14, R12', R13', X et Y sont comme définis dans le descriptif.

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