Use of bisphosphonates for otosclerosis

Details Use of bisphosphonates for otosclerosis Use of bisphosphonates for otosclerosis

A - Human Necessities

61

K

A61K 31/675 (2006.01) A61K 31/66 (2006.01) A61P 27/16 (2006.01)

Patent

CA 2536184

A method of treating otosclerosis in a human in need thereof by administering a bisphosphonate in a defined dosing schedule. The invention demonstrates an effective response and sustained benefit in the treatment of otosclerosis. Particularly, the method involves administration of a bisphosphonate in a stepped-up dosage amount, e.g., in a dose that is at least one and a half times the recommended dose for osteoporosis. It also includes administration of a time­ dependent dose of more than one bisphosphonate, specifically, alternating administration of a first bisphosphonate with a second bisphosphonate. The inventive method further includes intravenous administration of a bisphosphonate, and optionally oral administration of a bisphosponate. The present invention further contemplates a kit for facilitating the alternating bisphosphonate dosing schedule.

L'invention concerne un procédé pour traiter l'otosclérose chez un humain souffrant de cette maladie, comprenant l'administration d'un biphosphonate selon un schéma posologique défini. Le procédé de l'invention permet de répondre efficacement au problème et il est bénéfique dans le traitement de l'otosclérose. En particulier, le procédé comprend l'administration d'un biphosphonate dans une quantité de dosage accrue, par exemple un dosage représente au moins une fois et demie le dosage recommandé pour l'ostéoporose. Le procédé comprend également l'administration d'un dosage temporel comprenant plus d'un biphosphonate, de manière spécifique, l'administration en alternance d'un premier biphosphonate et d'un second biphosphonate. Le procédé de l'invention comprend, de plus, une administration par intraveineuse d'un biphosphonate, et éventuellement l'administration orale d'un biphosphonate. L'invention concerne, en outre un kit facilitant le schéma posologique en alternance du biphosphonate.

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