Use of xanthophylls, astaxanthin e.g., for treatment of...

Details Use of xanthophylls, astaxanthin e.g., for treatment of... Use of xanthophylls, astaxanthin e.g., for treatment of...

A - Human Necessities

61

K

A61K 31/122 (2006.01) A61K 31/23 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2388785

The use of at least one type of xanthophylls for the production of a medicament for suppression of excessive Th1 cell mediated immune responses and stimulation of Th2 cell mediated immune responses in a patient during ongoing infection and/or inflammation in said patient is disclosed. Excessive Th1 cell mediated immune responses are caused by such autoimmune diseases and chronic viral and intracellular bacterial infections as Psoriasis vulgaris, Multiple sclerosis (MS), Rheumatoid arthritis, Crohn's disease, Insulin-dependent diabetes mellitus, Tuberculosis (TB), Acute graft-versus-host disease (transplant rejection) and HIV virus infection. The preferred type of xanthophyll is astaxanthin, particularly in a form esterified with fatty acids, obtainable by for example culturing the algae Haematococcus sp. Further, a method of suppressing excessive Th1 mediated immune responses and stimulating Th2 cell mediated immune responses in a patient during ongoing infection and/or inflammation in said patient is disclosed.

Cette invention concerne l'utilisation d'au moins un type de xanthophylles pour la fabrication d'un médicament destiné à supprimer des réponses immunitaires excessives à médiation par cellules Th1 et à stimuler les réponses immunitaires à médiation par cellules Th2 chez un patient atteint d'une infection et/ou d'une inflammation persistante. Les réponses immunitaires excessives à médiation par cellules Th1 sont provoquées par des maladies auto-immunes et des infections bactériennes virales et intracellulaires chroniques telles que le Psoriasis vulgaris, la sclérose en plaques, la polyarthrite ruhmatoïde, la maladie de Crohn, le diabète sucré insulino-dépendant, la tuberculose, la réaction aiguë du greffon contre l'hôte (rejet du transplant) et l'infection à VIH. Le type préféré de xanthophylle est l'astaxanthine, en particulier sous sa forme estérifiée avec des acides gras que l'on obtient par culture de l'algue Haematococcus sp . L'invention concerne également une méthode permettant de supprimer des réponses immunitaires excessives à médiation par cellules Th1 et de stimuler les réponses immunitaires à médiation par cellules Th2 chez un patient atteint d'une infection et/ou d'une inflammation persistante.

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