Aromatic sulfonyl alpha-cycloamino hydroxamic acid compounds

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 213/89 (2006.01) A61K 31/35 (2006.01) A61K 31/40 (2006.01) A61K 31/445 (2006.01) C07C 317/44 (2006.01) C07D 207/16 (2006.01) C07D 211/54 (2006.01) C07D 213/30 (2006.01) C07D 213/64 (2006.01) C07D 213/82 (2006.01)

Patent

CA 2283272

An aromatic sulfonyl alpha-cycloamino hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as is a treatment process that comprises administering a contemplated aromatic sulfonyl alpha- cycloamino hydroxamic acid compound in an MMP enzyme-inhibiting effective amount to a host having a condition associated with pathological matrix metalloprotease activity.

La présente invention concerne un composé aromatique d'acide sulfonyl alpha-cycloamino hydroxamique qui inhibe notamment une activité de métalloprotéase matricielle (MMP). La présente invention concerne également un procédé de traitement qui consiste à administrer le composé aromatique d'acide sulfonyl alpha-cycloamino hydroxamique en question, à raison d'une quantité efficace destinée à inhiber l'activité d'un enzyme MMP, à un hôte présentant un état associé à une activité pathologique de métalloprotéase matricielle.

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