C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/89 (2006.01) A61K 31/35 (2006.01) A61K 31/40 (2006.01) A61K 31/445 (2006.01) C07C 317/44 (2006.01) C07D 207/16 (2006.01) C07D 211/54 (2006.01) C07D 213/30 (2006.01) C07D 213/64 (2006.01) C07D 213/82 (2006.01)
Patent
CA 2283272
An aromatic sulfonyl alpha-cycloamino hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as is a treatment process that comprises administering a contemplated aromatic sulfonyl alpha- cycloamino hydroxamic acid compound in an MMP enzyme-inhibiting effective amount to a host having a condition associated with pathological matrix metalloprotease activity.
La présente invention concerne un composé aromatique d'acide sulfonyl alpha-cycloamino hydroxamique qui inhibe notamment une activité de métalloprotéase matricielle (MMP). La présente invention concerne également un procédé de traitement qui consiste à administrer le composé aromatique d'acide sulfonyl alpha-cycloamino hydroxamique en question, à raison d'une quantité efficace destinée à inhiber l'activité d'un enzyme MMP, à un hôte présentant un état associé à une activité pathologique de métalloprotéase matricielle.
Becker Daniel P.
Boehm Terri L.
Decrescenzo Gary A.
Getman Daniel P.
Li Madeleine H.
Monsanto Company
Osler Hoskin & Harcourt Llp
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