Nucleic acids, proteins, and antibodies

Details Nucleic acids, proteins, and antibodies Nucleic acids, proteins, and antibodies

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C07K 5/00 (2006.01) C07K 14/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 1/20 (2006.01) C12N 5/00 (2006.01) C12N 15/63 (2006.01) C12P 21/06 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2393954

The present invention relates to novel ovarian related polynucleotides and the polypeptides encoded by these polynucleotides herein collectively known as "ovarian antigens", and the use of such ovarian antigens for detecting disorders of the ovaries and/or breast, particularly the presence of ovarian and/or breast cancer and ovarian and/or breast cancer metastases. More specifically, isolated ovarian associated nucleic acid molecules are provided encoding novel ovarian associated polypeptides. Novel ovarian polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human ovarian associated polynucleotides and/or polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to the ovaries and/or breast, including ovarian and/or breast cancer, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting the production and function of the polypeptides of the present invention.

Cette invention se rapporte à de nouveaux polynucléotides liés aux ovaires et aux polypeptides codés par ces polynucléotides, appelés collectivement "antigènes ovariens", ainsi qu'à l'utilisation de ces antigènes ovariens pour détecter des troubles des ovaires et/ou des seins, en particulier la présence de cancer des ovaires et/ou du sein et des métastases de cancers des ovaires et/ou du sein. Cette invention concerne plus spécifiquement des molécules d'acide nucléique associées aux ovaires et isolées, codant ces nouveaux polypeptides associés aux ovaires, ainsi que de nouveaux polypeptides ovariens et des anticorps qui se fixent à ces polypeptides. Cette invention concerne en outre des vecteurs, des cellules hôtes, et des procédés synthétiques et de recombinaison servant à produire des polynucléotides et/ou des polypeptides associés aux ovaires humaines, ainsi que des procédés diagnostiques et thérapeutiques utiles dans le diagnostic, le traitement, la prévention et/ou le pronostic des troubles liés aux ovaires et/ou aux seins, y compris le cancer des ovaires et/ou du sein, ainsi que des procédés thérapeutiques de traitement de ces troubles. Cette invention concerne enfin des procédés de criblage servant à identifier des agonistes et des antagonistes de ces polynucléotides et polypeptides, ainsi que des procédés et/ou des compositions servant à inhiber la production et les fonctions de ces polypeptides.

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