Oral vaccines for producing mucosal immunity

Details Oral vaccines for producing mucosal immunity Oral vaccines for producing mucosal immunity

A - Human Necessities

61

K

A61K 31/20 (2006.01) A61K 39/02 (2006.01) A61K 39/118 (2006.01) A61P 31/04 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2737684

Embodiments of this invention include lipid-based immunogenic compositions (adjuvants or carriers) useful for oral or gastrointestinal administration for improving mucosal immune responses in animals vaccinated for a variety of bacterial infections. In certain embodiments, lipid compositions of this invention include a mixture of fatty acids having different chain lengths, thereby providing desired physico-chemical properties. When a bacterial antigen is mixed with a lipid-based adjuvant or carrier, the resulting composition elicits improved mucosal immune responses and thereby decreases infections and sequellae of disease caused by Chlamydia or Helicobacter.

Des modes de réalisation de l'invention concernent notamment des compositions immunogènes à base de lipides (adjuvants ou excipients) pour administration gastrointestinal en vue d'améliorer les réponses immunitaires mucosales chez des animaux vaccinés contre diverses infections bactériennes. Dans certains modes de réalisation, des compositions lipides de l'invention comportent notamment un mélange d'acides gras présentant différentes longueurs de chaînes, ce qui permet d'obtenir les propriétés physico-chimiques souhaitées. Lorsqu'un antigène bactérien est mélangé avec un adjuvant ou un excipient à base de lipide, la composition qui en résulte élicite des réponses immunitaires mucosales améliorées, et permettent de réduire les infections par des maladies et leurs séquelles provoquées par  Chlamydia ou Helicobacter.

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