Human g-protein coupled receptors

Details Human g-protein coupled receptors Human g-protein coupled receptors

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2289046

Two human G-protein coupled receptor polypeptides and DNA (RNA) encoding each of such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides. Also disclosed are diagnostic methods for detecting a mutation in the nucleic acid sequence of each of the G-protein coupled receptors.

L'invention concerne deux polypeptides récepteurs couplés par des protéines G et l'ADN (ARN) codant chacun de ces polypeptides ainsi qu'un procédé de production de ces polypeptides par génie génétique. L'invention concerne également des procédés d'utilisation de ces polypeptides pour identifier des antagonistes et des agonistes de ces polypeptides. De plus, l'invention concerne des méthodes de diagnostic permettant de détecter une mutation dans la séquence nucléotidique de chacun des récepteurs couplés par des protéines G.

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