Device for processing biological specimens for analysis of...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01) B01L 3/00 (2006.01) C12M 1/02 (2006.01) C12N 15/00 (2006.01) G01N 1/31 (2006.01) G01N 35/00 (2006.01)

Patent

CA 2068891

2068891 9107486 PCTABS00005 A system is provided for the automated detection of target nucleic acid sequences in which multiple biological samples are individually incorporated into matrices within carriers in a two-dimensional format. The matrix carrier is an inexpensive, disposable unit that represents a closed system separating the specimens. The system integrates sample preparation within the matrix and facilitates biochemical reactions, addition of reagents and washes, removal of waste fluids, temperature control and the automated processing thereof. The carriers are processed in stepwise treatments that expose, amplify, and detect the presence or absence of specific genetic entities in each sample. The nucleic acids or other desired biological components held within the matrices are treated by one or more of the techniques such as amplification, electrophoresis, analyte-receptor binding or hybridization as selected for the desired analysis.

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