C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/37 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2524030
The invention relates to a method for detecting an infectious prion protein exhibiting an improved sensitivity. For this purpose, a heterologue non- pathogenic protease-sensitive prio protein is added to an examined sample. When the infectious prion protein PrPSc is present in said sample, the prion protein is transformed into protease-resistant prion aggregates by an asymmetric spontaneous interaction.
Procédé de détection d'une protéine prionique infectieuse, présentant une sensibilité améliorée. A cet effet, une protéine prionique hétérologue non pathogène sensible aux protéases est ajoutée à un échantillon à analyser. En cas de présence de la protéine prionique infectieuse PrPSc dans l'échantillon, la protéine prionique est transformée par interaction spontanée asymétrique en agrégats prioniques résistant aux protéases.
Borden Ladner Gervais Llp
F. Hoffmann-La Roche Ag
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