C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 38/47 (2006.01) A61K 47/48 (2006.01) C07K 16/30 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 9/24 (2006.01) C12P 21/02 (2006.01) C12P 21/08 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2062047
The invention relates to fusion proteins for prodrug activation of the general formula huTuMAb-L-.beta.-Gluc, where huTuMAb is a humanized or human tumor-specific monoclonal antibody or a fragment thereof, L is linker, and .beta.-Gluc comprises human .beta.-glucuronidase. These fusion proteins are prepared by genetic manipulation. huTuMAb ensures the specific localization of tumors, L connects huTuMAb to .beta.-Gluc in such a way that the specific properties of the two fusion partners are not imparied, and .beta.-Gluc activates a suitable prodrug compound by elimination of glucuronic acid, where a virtually autologous system for use in humans is provided by the humanized or human fusion partners.
Bosslet Klaus
Czech Joerg
Hoffman Dieter
Kolar Cenek
Sedlacek Hans-Harald
Behringwerke Aktiengesellschaft
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
LandOfFree
Fusion proteins for prodrug activation, the preparation and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Fusion proteins for prodrug activation, the preparation and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Fusion proteins for prodrug activation, the preparation and... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1422647