Azafused cyclin dependent kinase inhibitors

Details Azafused cyclin dependent kinase inhibitors Azafused cyclin dependent kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 231/56 (2006.01) A61K 31/416 (2006.01) A61K 31/437 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07D 401/12 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2621983

In its many embodiments, the present invention provides compounds (I) which are a novel class of 4- cyano, 4-amino, and 4-aminomethyl derivatives of pyrazolo[1,5-a]pyridine, pyrazolo[1,5-c]pyrimidine, and 2H-Indazole compounds and 5-cyano, 5-amino, and 5-aminomethyl derivatives of imidazo[1,2-a]pyridine and imidazo[1,5-a]pyrazine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions. Formula (I) wherein X is C or N.

Dans ses nombreux modes de réalisation, la présente invention concerne une nouvelle classe de dérivés 4-cyano, 4-amino, et 4-aminométhyl des composés pyrazolo[1,5-a]pyridine, pyrazolo[1,5-c]pyrimidine, et 2H-indazole, et de dérivés 5-cyano, 5-amino, et 5-aminométhyl des composés imidazo[1,2-a]pyridine et imidazo[1,5-a]pyrazine pouvant servir d'inhibiteurs des kinases dépendantes des cyclines (CDK). Cette invention concerne également des procédés de préparation de ces composés, des compositions pharmaceutiques contenant un ou plusieurs desdits composés, des procédés pour préparer des formulations pharmaceutiques comprenant un ou plusieurs de ces composés, ainsi que des procédés pour traiter, prévenir, inhiber, ou améliorer une ou plusieurs maladies qui sont associées avec les CDK à l'aide desdits composés ou desdites compositions pharmaceutiques.

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