Method of enhancing insulin action

A - Human Necessities – 61 – K

Patent

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A61K 31/505 (2006.01) A61K 31/52 (2006.01) A61K 31/522 (2006.01)

Patent

CA 2372948

A category of hydroxyalkyl-substituted xanthines are useful in treating patients suffering from disorders associated with impaired glucose metabolism or impaired insulin function. Use of these compounds, for example, restores insulin responsiveness in otherwise insulin-resistant Type 2 diabetic patients, thus reducing elevated blood glucose levels. The subject compounds also act to restore certain defects of lipid metabolism and to enhance the effects of insulin in general. Insulin-enhancing compositions and methods of treating disorders of glucose metabolism are provided.

Une catégorie de xanthiques substituées par un hydroxyalkyle est utile pour traiter des patients atteints de troubles associés à un métabolisme d'intolérance au glucose ou à une fonction déficiente de l'insuline. L'utilisation de ces composés restaure, par exemple, la réponse insulinique chez des patients diabétiques (type 2) résistants à l'insuline, ce qui permet de réduire les niveaux élevés de glucose dans le sang. Les composés du sujet agissent également de façon à restaurer le métabolisme lipidique et à améliorer les effets de l'insuline en général. L'invention concerne également des compositions améliorant les effets de l'insuline et des procédés permettant de traiter le métabolisme du glucose.

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