Novel inhibitors of the integrin .alpha.v.beta.3

Details Novel inhibitors of the integrin .alpha.v.beta.3 Novel inhibitors of the integrin .alpha.v.beta.3

C - Chemistry, Metallurgy

07

D

C07D 213/74 (2006.01) A61K 31/44 (2006.01) A61K 31/505 (2006.01) A61P 9/10 (2006.01) C07C 257/14 (2006.01) C07C 279/08 (2006.01) C07D 213/30 (2006.01) C07D 233/48 (2006.01) C07D 233/88 (2006.01) C07D 235/30 (2006.01) C07D 239/42 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2382850

The invention relates to novel compounds of formula (I) which are biologically active when present as ligands of the integrin .alpha.v.beta.3: X-Y-Z-R1-CH2- R2(R4)-CH2-CO-R5 wherein the meaning of X, Y, Z, R1, R2, R4 and R5 is given in Claim 1. The invention also relates to the physiologically acceptable salts and solvates of said compounds.

L'invention concerne de nouveaux composés de formule (I) : X-Y-Z-R?1¿-CH¿2?-R?2¿(R?4¿)-CH¿2?-CO-R?5¿, qui exercent une activité biologique en tant que ligands de l'intégrine .alpha.¿v?.beta.¿3?. Dans la formule (I), X, Y, Z, R?1¿, R?2¿, R?4¿ et R?5¿ ont la signification indiquée dans la revendication 1. L'invention concerne également les sels et solvates physiologiquement tolérables desdits composés.

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