C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01) C07H 21/02 (2006.01) C07K 14/47 (2006.01) C07K 17/00 (2006.01) C12N 1/20 (2006.01) C12N 5/10 (2006.01) C12N 15/00 (2006.01) C12N 15/63 (2006.01) C12P 21/04 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2328405
Nucleic acid molecules derived from the antisense strand of a novel ubiquitously expressed gene, RUR-1, are provided. The RUR-1 antisense nucleic acids code for polypeptides which are expressed preferentially in tumor samples and tumor-derived cell lines. Nucleic acids comprising the ubiquitously expressed gene and fragments thereof also are provided. Also provided are polypeptides encoded by those nucleic acids, functional homologs, modifications and variants of the foregoing, useful fragments of the foregoing, as well as therapeutics and diagnostics related thereto.
L'invention concerne des molécules d'acides nucléiques dérivées du brin antisens d'un nouveau gène à expression ubiquiste, RUR-1. Les acides nucléiques antisens RUR-1 codent des polypeptides exprimés de préférence dans les prélèvements de tumeur et les lignées cellulaires d'origine tumorale. L'invention concerne également des acides nucléiques renfermant le gène à expression ubiquiste considéré et des fragments de ce gène. L'invention concerne en outre des polypeptides codés par lesdits acides nucléiques, des homologues fonctionnels, des modifications et des variants ainsi que des fragments utiles des éléments qui précèdent, et aussi des procédés thérapeutiques et diagnostiques correspondants.
Boon-Falleur Thierry
Van Den Eynde Benoit
Ludwig Institute For Cancer Research
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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