Transgenic rats containing in their genome at least one...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/89 (2006.01) A01K 67/027 (2006.01) C07K 7/14 (2006.01) C12N 9/64 (2006.01) C12N 15/16 (2006.01) C12N 15/57 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2076194

Abstract Transgenic rats containing in their genome at least one human gene which participates in blood pressure control The present invention relates to transgenic rats in the genome of which at least one human gene is integrated the gene product of which participates in blood pressure control. More specifically, the invention relates to transgenic rats and their offspring exhibiting increased blood pressure (>90/>140 mm Hg) or high blood pressure (>95/>160 mm Hg). Finally, the invention relates to processes for the production of the transgenic rats of the present invention and their offspring and their use for pharmacological tests.

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