C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/16 (2006.01) A01K 67/033 (2006.01) C07K 7/23 (2006.01) C07K 14/575 (2006.01) C12N 5/16 (2006.01) C12N 15/11 (2006.01) C12P 21/00 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2414635
A novel gonadotropin-releasing hormone (GnRH) occurring in octopus which is a mollusk is found out and the structure and action thereof are clarified, thereby providing novel peptides which are usable as reagents for clarifying the correlation between the structure and activity of GnRH and signal processing mechanism in the nerve system of higher animals and as basic compounds for developing pesticides or drugs. Namely, peptides represented by the following amino acid sequence formula (I) and having a GnRH activity: <Glu- Zaa-Zaa-His-Zaa-Ser-Zaa-Zaa-Zaa Zaa-Pro-Gly-NH2 (I) wherein <Glu represents pyroglutamic acid; and Zaa represent an arbitrary amino acid; in particular, a peptide represented by the following amino acid sequence formula (1): <Glu-Asn- Tyr-His-Phe-Ser-Asn-Gly-Trp-His-Pro-Gly-NH2 (I) wherein <Glu represents pyroglutamic acid.
L'invention porte sur une nouvelle gonalibérine (GnRH) découverte dans la pieuvre (un mollusque) et dont la structure et l'action ont été clarifiées, et sur de nouveaux peptides associés servant de réactifs pour clarifier la corrélation entre d'une part la structure et l'activité de la GnRH, et d'autre part le mécanisme de traitement des signaux du système nerveux des animaux supérieurs,, ce qui constitue des éléments de base pour la mise au point de pesticides et de médicaments. Il s'agit de peptides à activité de GnRH dont la formule (I) de la séquence d'acides aminés est la suivante: <Glu-Asn-Tyr-His-Phe-Ser-Asn-Gly-Trp-His-Pro-Gly-NH¿2
Iwakoshi Eiko
Kuroda Kyoko
Minakata Hiroyuki
Smart & Biggar
Suntory Limited
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