Long-term expression of gene products by transforming muscle...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/86 (2006.01) A61K 38/18 (2006.01) A61K 38/27 (2006.01) A61K 48/00 (2006.01) C07K 14/505 (2006.01) C12N 15/12 (2006.01)

Patent

CA 2269654

A process for increasing the circulating levels of gene products in a primate for extended period of time is provided. In accordance with that process, muscle cells of the mammal are transformed with an expression vector that contains a polynucleotide that encodes the gene product and which vector drives expression in the muscle.

Procédé pour accroître les taux de circulation des produits génétiques chez le primate pendant une période prolongée. Avec ce procédé les cellules musculaires du mammifère sont transformées avec un vecteur d'expression qui contient un polynucléotide codant le produit génétique, ce vecteur commandant l'expression du produit dans le muscle.

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