C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/705 (2006.01) A61K 38/17 (2006.01) C12N 15/62 (2006.01)
Patent
CA 2531228
The present invention provides novel therapeutic molecules called Culling Fusion Proteins (CFPs) that allow the continuous removal of therapeutic targets from extracellular space by exploiting the endosome/lysosome intracellular degradation pathway, and the exocytotic pathway in a combined manner. The products of the invention, by appropriately utilizing the cellular endocytosis and exocytosis mechanism, can be recycled multiple times by cells to eliminate undesired molecules, therefore such therapeutic molecules can be administered at low concentration.
Nouvelles molécules thérapeutiques appelées protéines de fusion de triage (CFP) qui permettent l'élimination en continu de cibles thérapeutiques de l'espace extracellulaire par exploitation de la voie de dégradation intracellulaire endosome / lysosome et de la voie exocytotique de manière combinée. L'utilisation appropriée du mécanisme cellulaire de l'endocytose et de l'exocytose permet le recyclage multiple des produits selon la présente invention par les cellules pour éliminer les molécules indésirables, lesdites molécules thérapeutiques pouvant donc être administrées à une faible concentration.
Applied Research Systems Ars Holding N.v.
Kirby Eades Gale Baker
LandOfFree
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