Stable tpo-containing lyophilized compositions

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/19 (2006.01) A61K 9/19 (2006.01) A61K 47/18 (2006.01) A61K 47/26 (2006.01) A61K 47/42 (2006.01)

Patent

CA 2223749

A freeze-dried composition containing TPO which comprises thrombopoietin (TPO) protein and saccharides as pharmaceutically acceptable additives. The composition may further contain at least one pharmaceutically acceptable additive selected from among surfactants, amino acids and proteins. Thus a decrease in the activity of TPO employed as the active ingredient can be inhibited or regulated during prolonged storage.

La présente invention concerne une composition lyophilisée stable contenant de la protéine thrombopoïétine (TPO) et des saccharides en tant qu'additifs acceptables en pharmacie. Cette composition peut contenir en outre au moins un additif acceptable en pharmacie, choisi parmi des agents tensio-actifs, des acides aminés et des protéines. Ainsi, la diminution de l'activité de la TPO utilisée comme ingrédient actif peut être inhibée ou régulée durant un stockage prolongé.

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