Process for the preparation of pyrazolylaminoquinazoline...

C - Chemistry – Metallurgy – 07 – F

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C07F 9/02 (2006.01)

Patent

CA 2650518

The invention relates to a new process useful in the preparation of pharmaceutical compounds such as 2-{ethyl[3-({4-[(5-{2-[(3-fluorophenyl)amino]-2-oxoethyl}-1H-pyrazol-3-yl)amino]quinazolin-7-yl}oxy)propyl]amino}ethyl dihydrogen phosphate (AZD1152) and intermediates used therein.

L'invention concerne un nouveau procédé utile pour préparer des composés pharmaceutiques tels que le 2-{éthyl[3-({4-[(5-{2-[(3-fluorophényl)amino]-2-oxoéthyl}-1H-pyrazol-3-yl)amino]quinazolin-7-yl}oxy)propyl]amino}éthyle dihydrogénophosphate (AZD1152). L'invention concerne également des intermédiaires utilisés dans le cadre dudit procédé.

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