Immunogenic composition and method of developing a vaccine...

A - Human Necessities – 61 – K

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A61K 39/21 (2006.01) A61K 39/12 (2006.01) A61P 31/18 (2006.01)

Patent

CA 2541497

The present invention relates to an immunogenic composition. More particularly, the present invention is a composition directed to eliciting an immune response to at least one binding site of Cyclophilin A on the HIV capsid protein. The present invention contemplates three categories of embodiments: protein or protein fragments, messenger RNA, or DNA/RNA. DNA/RNA compositions may be either naked or recombinant. The present invention further contemplates use with a variety of immune stimulants.

La présente invention concerne une composition immunogène. Cette invention concerne en particulier une composition visant à déclencher une réponse immunitaire à au moins un site de liaison de la Cyclophiline A sur la protéine capside du VIH. Cette invention se penche sur trois catégories de modes de réalisation: protéine ou fragments de protéine, ARN messager, ou ADN/ARN. Les compositions d'ADN/ARN peuvent être nues ou recombinantes. Cette invention porte par ailleurs sur l'utilisation de ces compositions avec une variété de stimulants immunitaires.

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