Mutants of streptococcal toxin a and methods of use

Details Mutants of streptococcal toxin a and methods of use Mutants of streptococcal toxin a and methods of use

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) A61K 39/09 (2006.01) C07K 14/315 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2221480

This invention is directed to mutant SPE-A toxins or fragments thereof, vaccine and pharmaceutical compositions, and methods of using the vaccine and pharmaceutical compositions. The preferred SPE-A toxin has at least one amino acid change and is substantially non-lethal compared with the wild type SPE-A toxin. The mutant SPE-A toxins can form vaccine compositions useful to protect animals against the biological activities of wild type SPE-A toxin.

L'invention concerne des toxines SPE-A mutantes ou des fragments de celles-ci, des compositions vaccinales ou pharmaceutiques, ainsi que des procédés d'utilisation de ces compositions. La toxine SPE-A préférée comprend au moins un changement d'acide aminé et elle n'est généralement pas mortelle par comparaison avec la toxine SPE-A de type sauvage. Les toxines SPE-A mutantes peuvent former des compositions vaccinales utiles pour protéger des animaux contre les effets biologiques de la toxine SPE-A de type sauvage.

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