Inhibitors of viral integrase and methods of use

Details Inhibitors of viral integrase and methods of use Inhibitors of viral integrase and methods of use

C - Chemistry, Metallurgy

07

K

C07K 7/08 (2006.01) A61K 38/10 (2006.01) A61P 31/18 (2006.01) C12N 15/11 (2006.01) G01N 33/573 (2006.01) C12N 9/12 (2006.01)

Patent

CA 2755866

Described herein are compositions and methods for inhibiting HIV integrase activity. Also described are methods of identifying agents that inhibit HIV integrase for use in treating or preventing HIV. Also disclosed are methods of identifying agents that inhibit HIV viral mutants that are resistant to integrase inhibitors.

L'invention concerne des compositions et des méthodes pour inhiber l'activité de l'intégrase du HIV. L'invention concerne également des méthodes pour identifier des agents qui inhibent l'intégrase du HIV, utilisées pour traiter ou prévenir le HIV. L'invention concerne enfin des méthodes d'identification d'agents inhibant des mutants viraux du HIV qui résistent aux inhibiteurs de l'intégrase.

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