Medical devices having self-forming rate-controlling barrier...

Details Medical devices having self-forming rate-controlling barrier... Medical devices having self-forming rate-controlling barrier...

A - Human Necessities

61

L

A61L 31/04 (2006.01) A61L 29/04 (2006.01) A61L 29/16 (2006.01) A61L 31/16 (2006.01)

Patent

CA 2578742

Therapeutic-agent-releasing medical devices are provided herein, which contain a rate controlling release region that includes a biodisintegrable agent and a biostable low glass transition temperature polymer. Upon contact (e.g., implantation or insertion) of the medical device with a subject, at least the surface of the release region becomes depleted of the biodisintegrable agent, and the low glass transition temperature polymer migrates to occupy at least a portion of the volume that is created by the departure of the biodisintegrable agent, thereby forming a barrier layer for therapeutic agent remaining within the device.

L'invention concerne des dispositifs médicaux d'administration d'agents thérapeutiques, qui contiennent une zone de libération à commande de débit qui comporte un agent biodésintégrable et un polymère à faible température de transition vitreuse biostable. Lors du contact (par exemple lors de l'implantation ou de l'insertion) du dispositif médical avec le patient, au moins la surface de la zone d'administration s'appauvrit en agent biodésintégrable, et le polymère à faible température de transition vitreuse migre et occupe au moins une partie du volume créé par le départ de l'agent biodésintégrable, une couche barrière se forme alors pour l'agent thérapeutique restant dans ledit dispositif.

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