Spacer moiety for poly(ethylene glycol) -modified peptides

Details Spacer moiety for poly(ethylene glycol) -modified peptides Spacer moiety for poly(ethylene glycol) -modified peptides

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2525399

The present invention relates to a compound comprising a peptide moiety, a spacer moiety and a water-soluble polymer moiety such as a poly(ethylene glycol) moiety. The spacer moiety is between the peptide moiety and the water- soluble polymer moiety. The spacer moiety has the structure: -NH-(CH2).alpha.- [O-(CH2).beta.].gamma.-O.delta.-(CH2).epsilon.-Y~- wherein .alpha., .beta., .gamma., .delta.,and .epsilon. are each integers whose values are independently selected.

L'invention porte sur un composé comprenant un fragment de peptide, un fragment espaceur et un fragment de polymère hydrosoluble, par exemple de poly(éthylène glycol). Le fragment espaceur est situé entre le fragment de peptide et le fragment de polymère hydrosoluble. Le fragment espaceur présente la structure suivante: -NH-(CH¿2?)¿a?-[O-(CH¿2?)¿.szlig.?]¿??-O¿d?-(CH¿2?)¿e?-Y-- dans laquelle a, .szlig., ?, d, et e sont chacun un entier dont la valeur est choisie indépendamment.

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