Binding proteins inhibiting the vegf-a receptor interaction

Details Binding proteins inhibiting the vegf-a receptor interaction Binding proteins inhibiting the vegf-a receptor interaction

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01)

Patent

CA 2742241

The present invention relates to binding proteins specific for VEGF-A, in particular to recombinant binding proteins comprising a binding domain, which inhibits VEGF-Axxx binding to VEGFR-2. Examples of such binding proteins are proteins which comprise an ankyrin repeat domain with the desired binding specificity. The binding proteins are useful in the treatment of cancer and other pathological conditions, e.g. eye diseases such as age- related macular degeneration.

La présente invention concerne des protéines de liaison spécifiques de VEGF-A, en particulier des protéines de liaison recombinantes comprenant un domaine de liaison, qui inhibe la liaison de VEGF-Axxx à VEGFR-2. Des exemples de telles protéines de liaison sont des protéines qui comprennent un domaine de répétition dankyrine ayant la spécificité de liaison souhaitée. Les protéines de liaison sont utiles dans le traitement du cancer et dautres affections pathologiques, par exemple des maladies ophtalmiques telles que la dégénérescence maculaire liée à lâge.

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